Jurgen Klopp has confirmed that Alisson and Fabinho will miss Liverpool's Premier League game against Watford on Saturday.
The pair have been on international duty for Brazil with Fabinho starting his side's 4-1 defeat to Uruguay on Thursday, while his club-mate was on the bench.
The chances of either being available in time for the Saturday lunchtime kick off were always remote, but Klopp has finally confirmed their absences in his pre-match press conference.
Instead, they will be flying straight to Madrid in preparation for the Reds' Champions League meeting with Atletico on Tuesday evening.
"The last game they played in a red list country was Colombia so next Thursday it will be 10 days and then they can fly back [from Madrid to UK]," he said.