Harry Kane grabbed his first Premier League goal of the season as Spurs came from a goal down to beat Newcastle 3-2 at St James' Park.
Steve Bruce took charge of his 1000th game in football management but was unable to mastermind his side to a victory in the first match following Newcastle's takeover.
The game was temporarily suspended due to a medical emergency in the stands, and the fan who was taken ill is now in a stable condition in hospital.
Newcastle enjoyed a fast start when Javier Manquillo's cross was met by Callum Wilson, and the England striker gave the home side a second-minute lead.
Spurs were initially poor in their response to going behind, but did find themselves level a quarter of an hour later when Tanguy Ndombele's strike found the top corner of Karl Darlow's net.